Sunday, September 23, 2018

Ole Miss Can't Grow Enough Weed

It appears Ole Miss is losing it's monopoly on legally growing marijuana.  The Associated Press reported last week:


In a rare move, the U.S. government has approved the importation of marijuana extracts from Canada for a clinical trial, highlighting a new avenue for American researchers who have long had trouble obtaining the drug for medical studies.

The University of California San Diego’s Center for Medicinal Cannabis Research announced Tuesday the Drug Enforcement Administration has OK’d its plans to import capsules containing two key cannabis compounds — CBD and THC — from British Columbia-based Tilray Inc . to study their effectiveness in treating tremors that afflict millions of people, especially those over 65.

Marijuana remains illegal under federal law, making it impossible for researchers to simply obtain forms of the drug from one of the many medical marijuana programs approved by individual states — even a state with a pot culture as prevalent as California’s.

Instead, federal law dictates that researchers typically must obtain any weed for clinical trials through the National Institute on Drug Abuse, which uses cannabis grown at the University of Mississippi. Scientists have long complained about the difficulty of obtaining that marijuana, as well as its limited quality, variety and usefulness for clinical research.

The University of California San Diego researchers said they needed marijuana extracts in capsule form because it’s easier to monitor the doses that patients receive, compared to having patients smoke or vaporize it. They also believed many older patients would be reluctant to participate in the study if they had to inhale the drug, according to Dr. Fatta Nahab, a UCSD neurologist and the tremor study’s principal investigator.

NIDA doesn’t offer capsules, so the researchers spent about two years going through regulatory hoops to obtain permission to import the drug from Canada, where medical marijuana is federally legal and where recreational sales begin nationwide next month.

Paul Armentano, deputy director of the marijuana law reform organization NORML, said that illustrates how badly American researchers need alternative sources for cannabis. The House Judiciary Committee last week passed a bill to require the Justice Department to issue at least two more licenses to U.S. facilities to grow pot for research.

“It’s very telling that you have researchers in the U.S. willing to exert the patience and go through the regulatory hurdles to make this happen at the same time the United States has its own domestic supply source,” Armentano said.

Marijuana compounds have been imported for clinical trials before, including by Britain-based GW Pharmaceuticals, which won approval this year to sell its purified CBD capsule, Epidiolex, to treat severe forms of epilepsy — the first cannabis drug approved by the U.S. Food and Drug Administration. While GW Pharmaceuticals developed that drug in-house before bringing it to the U.S. for testing, Tilray, which recently became the first marijuana company to complete an initial public stock offering in the U.S., said it can work with researchers to develop the cannabis formulations they hope to study.

“It’s a really big milestone for Tilray and also just for the whole industry,” said Catherine Jacobson, Tilray’s director of clinical research. “Researchers in the U.S. have really been limited to doing research using dried flower. We have been able to prove to the FDA that we can manufacture investigational study drugs containing cannabinoids that meet their standards.”....

NIDA intends to expand how much marijuana the University of Mississippi grows for research. The agency’s contract with the university provides for the possibility of offering cannabis capsules, but it has not yet done so, said Don Stanford, assistant director of the Research Institute of Pharmaceutical Sciences at the university.

There is no drug designed to treat essential tremor, a shaking condition. Unlike Parkinson’s disease, which causes shaking when someone is not moving, people with essential tremors shake when they are, making everyday activities like writing, drinking and speaking difficult. The condition afflicts 10 million people nationally and millions more across the globe, according to the International Essential Tremor Foundation.

Many patients try to control the shaking by repurposing other drugs, such as blood pressure medicine, with limited success.

Nahab said he started looking into whether marijuana could be used to treat essential tremor after two patients showed sudden improvement after smoking pot or consuming CBD purchased online.

The FDA application outlined the drug formula — a 20:1 ratio of CBD to THC, to minimize any high study participants might feel — as well as its purity, toxicity, shelf life and other details. Researchers also had to get safety approvals from the university and present their plans to a California research advisory panel.

The university hopes to have 16 to 20 patients in the study, which will begin early next year. Researchers will monitor the tremors with a device placed on the wrist and record changes in the severity of the shaking.

Tilray is providing the drug and limited financial support but said it will have no role in reviewing the study’s results.

“Essential tremor is 10 times more common than Parkinson’s and yet nobody really knows about essential tremor,” Nahab said. “That we’re finally getting to a potential therapeutic option in an area that is untapped is a big deal.” Rest of article.

Kingfish note:  Meanwhile, Instagram King Dan Bilzerian, yes, that Dan Bilzerian, launched his own high-quality line of CBD oil products.  Posted below is the video of the launch party.



All kidding aside, the ban on research is dumb.  Marijuana is a plant.  Just because it can be misused doesn't mean it doesn't have any value on the medical side of things.  There is nothing unethical or immoral about studying its medical uses in a research laboratory.  

20 comments:

Anonymous said...

So the Trent Lott institute of pot cannot produce pot. Another one of his pet projects that fail, because there was no good reason for the National Institute to be placed at UM in the first place.

The only pot that Trent could justify at his alma mater, would be the pot for him to cook his pork fat in - again.

Anonymous said...

Not enough, just really poor quality, they are growing much better stuff in Madison and Rankin.

Anonymous said...

@557, don't leave out Jeff Davis county! They grow enough in one spot to take care of the Madison market. (Used to be covered from the north in Leake County until they busted up that large plantation a few years ago.)

And their stuff is supposed to be top notch. Might it be that the best of the Trent Lott material is used to take care of the hookers and thugs on the square Saturday nights, leaving only the poorer quality for the feds?

Anonymous said...

Could have been at the forefront, instead.....oh..$#...

Anonymous said...

@5:57

I don’t know what you’re talking about. I grow mine in Lincoln county, and it’s top notch.

Anonymous said...

*its

Anonymous said...

Wrong, it’s “it’s.” The pot grower was correct after all.

Anonymous said...

The leg humpers could have used a little something to loosen them up last night in the blue grass state. They were a bit tense and sensitive.

Anonymous said...

After legal Sport Betting & Lottery passed in our fine state legalizing marijuana will be Next. Tote that Duebee, Hammer the roach.

Anonymous said...

Why can't they make it in pill form?

It would preserve the monopoly.

Course, will Cindy Lou-who fight to retain the monopoly and the jobs at Ole Miss, or allow them to go out-of-state?

Anonymous said...

Where can I get this stuff (for research only)? Will settle for low grade. Axing for a friend.

Anonymous said...

I don't think this was Trent Lott's pork. The pot farm goes back to Jamie Whitten.

Anonymous said...

11:04 they already do, I think that's what they are importing...

Anonymous said...

The pot farm was at Ole Miss long before anybody heard of Trent Lott. But don't let that get in the way of changing the subject

Anonymous said...

Long before anybody heard of Trent Lott? Hell, back in 1971 Ole Miss, like many other college campuses weren't interested in pot, they were into hard drugs.

Realize you might not have heard of Lott until he held his bro-in-laws wallet while he screwed the country out of billions, but Lott thought a lot of himself long before that.

Anonymous said...

Lott was a cheerleader at OM before the pot farm. Cochran too.

Be smart! Not greedy! said...

To grow good pot, start in small flower pots, indoors. Then move to five gallon buckets (with vegetable miracle gro), at this point you can place them in a young pine thicket. Once they reach 3-4 feet tall, place them into a large hole, filled with miracle grow. Wrap strong fishing line around the perimeter, as deer love to eat marijuana plants. Plant no more than three plants in an area, to prevent being detected from above. Once the plants are outside and in the ground, do not tend to them more than once a month. Therefore it’s best to plant before several days of rain. Majority of people are caught because they tend the plants too often. A key piece of equipment is wireless game cameras, that send pictures directly to a burner phone. If you get pictures of people looking at your plants, don’t go back.

Anonymous said...

Can someone help me out, my brother in law is a cop and he hunts our family land.

Anonymous said...

@6:14

The State is full of land owned by senior citizens and by timber companies, neither of which do much more than ride the firelanes once a year, if that. Just trespass, if the plants are the right age when you plant them, you will only go on site a few times. Even if it’s land that is used, no one ventures into a pine thicket of 4-8 year old trees unless it is to clear firelanes. Just don’t leave a trail. Careful not to break branches, knock down thickets, etc. Or just tell your in law that it isn’t his land and to not come out anymore. Also, another thing to consider, is if your brother in law is a regular cop then more than likely he is a complete dumbass.

Anonymous said...

there are lots of option nowadays like this one https://www.gyo.green/cannabis-seedbanks/ace-seeds-cannabis-seeds



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