Drug only useful if taken at onset of infection.
It turns out hydoxycloroquine can be used to treat Covid-19 after all. The American Journal of Medicine reported in its January issue:
Hydroxychloroquine (HCQ) is an antimalarial/anti-inflammatory drug that impairs endosomal transfer of virions within human cells. HCQ is also a zinc ionophore that conveys zinc intracellularly to block the SARS-CoV-2 RNA-dependent RNA polymerase, which is the core enzyme of the virus replication. The currently completed retrospective studies and randomized trials have generally shown these findings: 1) when started late in the hospital course and for short durations of time, antimalarials appear to be ineffective, 2) when started earlier in the hospital course, for progressively longer durations and in outpatients, antimalarials may reduce the progression of disease, prevent hospitalization, and are associated with reduced mortality. In a retrospective inpatient study of 2541 patients hospitalized with COVID-19, therapy associated with an adjusted reduction in mortality was HCQ alone (hazard ratio [HR] = 0.34, 95% confidence interval [CI] 0.25-0.46, P <0.001) and HCQ with azithromycin (HR = 0.29, 95% CI 0.22-0.40, P <0.001). HCQ was approved by the US Food and Drug Administration in 1955, has been used by hundreds of millions of people worldwide since then, is sold over the counter in many countries, and has a well-characterized safety profile that should not raise undue alarm., Although asymptomatic QT prolongation is a well-recognized and infrequent (<1%) complication of HCQ, it is possible that in the setting of acute illness symptomatic arrhythmias could develop. Data safety and monitoring boards have not declared safety concerns in any clinical trial published to date. Rare patients with a personal or family history of prolonged QT syndrome and those on additional QT prolonging, contraindicated drugs (eg, dofetilide, sotalol) should be treated with caution and a plan to monitor the QTc in the ambulatory setting. A typical HCQ regimen is 200 mg bid for 5 days and extended to 30 days for continued symptoms. A minimal sufficient dose of HCQ should be used, because in excessive doses the drug can interfere with early immune response to the virus.
What a surprise. As yours truly said a few months ago, the drug seems to work if administered soon after infection. Get the test, test positive, start taking the drug immediately (with a doctor's supervision, of course.). However, once the virus takes out a lease and moves in the furniture, the drug loses its effectiveness. This article has just a slightly different take than what the medical establishment was telling us last summer.
28 comments:
Shame, shame...this after at least one study claiming HCQ had serious adverse effects on the heart was actually withdrawn because the data was possibly fabricated.
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Isn’t this the medication Trump took. The liberals called it snake oil. I wonder how many more would have lived had the left not interfered?
Oh the lives that could’ve been saved last year had the cyber bullied not jumped on OMB for uttering any kind word about HCL. And how about Ken Cleveland and MSBML and their wicked letter in the fall demanding Docs quit writing scripts for HCL? They look like assholes.
Cool, now do Ivermectin. How many people have died due to the lies of so called health experts? They were so desperate to hurt Trump and get the emergency use of the vaccines approved, that they didn't care how many had to die.
Too Little Too Late. The Sheeple have already been convinced the HCQ will kill you faster than Covid-19 and that Trump is stupid! They had to have a vaccine!
It’s still useless, most people don’t realize they have Covid until several days after onset. That is why most hospitals refused to use it, the patients they saw didn’t response to it and in fact in the case of my sister who actually was given the drug, she got sicker from it.
This piece was written early in the COVID epidemic and published on-line last August. The journal published it at a point in time when there were still controversies about the use of HCQ (and other drugs mentioned in the article). It was not an "endorsement" by the journal. The science in the article is now out of date. This same journal has also published a number of articles showing that the science of HCQ is weak/unproven. Don't be so fast to endorse the findings which were from science last June.
Nope, no way. Liberal media tells me otherwise. I must believe them. Orange man bad.
Now you know big pharma doesn’t want you to take something that’s cheap safe and effective , they want you to spend the big bucks. Trump was right.
@7:55am - BUT BUT... HOW CAN I CONTINUE TO CONFIRM MY BIAS AND IGNORANCE WITHOUT OUT OF DATE ANECDOTAL STUDIES AND FACEBOOK POSTS THAT I AGREE WITH IN ORDER TO OWN THE LIBS AND SCIENTISTS WITH MY SUPERIOR INTELLECT AND RESEARCH SKILLS?!?!
Soon we will find out wind and solar energy isn't a viable option. Too soon?
... That is why most hospitals refused to use it, the patients they saw didn’t response to it ...
Link?
Viable? Maybe. Reliable? No.
@9:40
Yeah and as soon as I drove my Tesla out of my heated garage, my battery dropped 45%. Luckily we have a charging station at the hospital.
@10:24am - Don’t be a poor, install a heating kit on your Tesla battery.
@10:58 AM
I plan to do so now. But living in Mississippi, I didn’t think I would need a battery heater.
"That is why most hospitals refused to use it" February 18, 2021 at 7:48 AM
Not only can you not provide a link ('my sister' is not a link), hospitals don't make drug-use decisions - prescribing physicians do.
Still waiting for something big to happen.
The excerpt you quoted doesn't say it works. It says administration early in treatment is "associated with" reduced mortality. Association doesn't imply causation.
10:24 if that's your gold standard for sustainable renewable energy, that tells me all I need to know about it. What happens when all charging stations are full of other EV's or the power grid is down for an extended length of time. I hope you don't stay home with the natural gas logs lit. I personally need to drive more than 15mins to get places and none of them have charging stations. I do go to the gas station about twice a week. Truck is full if I need it.
How many people died because the left loathed the advice given by the bad orange man. They did everything in their power to keep HCQ under wraps.
Remember the story of the man that died drinking fish tank cleaner? Turns out he was poisoned by his wifey?
And you wonder why people don’t trust the media.
It may be useful if you have had close contact with a known COVID infected person and immediately start taking it. That was basically what the early indications were, people who were already on it for other things tended to have fewer COVID cases which indicated a prophylactic effect. By the time you are running fever, get to a doctor, get tested, and get a prescription it is too late. HCQ is just about useless at that point.
@2:44 That was good speculation. But it didn't happen. Probably the best experimental group for your theory were lupus patients and others with rheumatology diseases who were already taking HCQ before the COVID pandemic hit. With your logic, they should have been prevented from serious disease. Unfortunately, that didn't happen. But it was a good idea.
Politics has no place in healthcare...
Those that lied about this drug should be punished...
It's as if they intentionally ignored the protocol as original put forth by Z. huh.
ORANGE MAN BAD!
Not quite sure about this research. I take 200mg 2/day for my arthritis and got a horrible case of COVID. Even after more than a month, I am still exhausted and have brain fog. I'm finally getting my sense of smell back.
The settled science sure seems to be changing a lot. I'd be shocked if politic pressure inserted itself into medicine! Shocked!! Next we'll hear that global warming was a hoax.
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