Wednesday, November 18, 2020

Moderna C19 Vaccine 94.5% Effective

 Pfizer rocked the world last week when it announced a Covid-19 vaccine that had a success rate of 95%.  Moderna followed up with its own Covid-19 vaccine that is just as effective but has less stringent requirements for storage.  The Wall Street Journal reported Monday: 

Moderna Inc. MRNA -4.00% said its experimental coronavirus vaccine was 94.5% effective at protecting people from Covid-19 in an early look at pivotal study results, the second vaccine to hit a key milestone in U.S. testing.

Ninety-five people in a 30,000-subject study developed Covid-19 with symptoms; of those, 90 had received a placebo and only five Moderna’s vaccine.

The findings move the vaccine closer to wide use because they indicate it is effective at preventing disease that causes symptoms, including severe cases. The trial is still under way.

The vaccine also showed signs of being safe, though researchers and regulators must wait for more-complete safety data from the study, expected later in November. Moderna said it plans to ask federal health authorities by early December to clear the vaccine. 

If greenlighted, the shot could go into distribution that month, making it one of the first Covid-19 vaccines to go into distribution in the U.S., where reported coronavirus cases and hospitalizations are surging.

“We may be in a place with a vaccine that has a big impact on the prevention of severe disease,” Moderna Chief Executive Stéphane Bancel said in an interview. “That will be an incredible win against this awful virus.”...

 Moderna’s initial data were reviewed by a committee of independent researchers monitoring the study. The findings provide only a rough snapshot of whether the vaccine works. The company plans to release additional results later, including effectiveness in specific groups such as the elderly and against infections that don’t produce symptoms.

 Moderna’s vaccine, like Pfizer’s, uses a new technology known as messenger RNA. It works by delivering genetic instructions that teach human cells to make a protein resembling one found on the surface of the coronavirus. That triggers an immune response designed to protect vaccinated people if they are later exposed to the actual virus...

 The logistics of getting both vaccines into the arms of people could be challenging because it will require the shots to be kept at a range of cold temperatures. Moderna’s vaccine must be shipped and kept in long-term storage at a below-freezing temperature equal to most home or medical freezer temperatures. Moderna said Monday it now expects its vaccine, after thawing, can remain stable in regular refrigerator storage for up to 30 days—longer than its previous estimate of seven days. Pfizer’s vaccine must be stored at even colder temperatures and then can be kept at standard refrigeration temperatures for about five days....

The FDA wants to see two months of safety monitoring for at least half of the 30,000 people in the trial, a milestone Moderna expects by the end of November. In the early look, the company said no significant safety concerns were reported, and the vaccine was generally well tolerated, with injection-site pain for some people after the first dose, and fatigue, headache and joint pain after the second.

If regulators do authorize the vaccine, the initial supply of doses will be limited—20 million, or enough for 10 million people, by the end of the year, Moderna forecasts. If the Pfizer vaccine is also authorized, federal officials said Monday they expect to be able to immunize about 20 million Americans during December.... Rest of article. 


25 comments:

Anonymous said...

Saw today where Pfizer has now met the requirements for requesting emergency use authorization and will do so in a few days. FDA has blocked off December 8-10 for meetings, presumably to consider this request and Moderna's if they also hit their threshold of positive cases.

Don't let this give you false confidence though. Even under the best of circumstances a mid-December vaccination will be useless against spreading the virus at Thanksgiving and Christmas gatherings. Until the vaccine is widely distributed we will see COVID cases and deaths continue and likely increase over the next few months. It will be the end of March at the earliest before vaccination results will show up in decreasing case counts, and more importantly in the death count.

We're closer, but ultimately we are not going to be any better off for a while yet.

Anonymous said...

false confidence? how about ticker tape parades. This is a big deal.

Anonymous said...

94% effective on a cold over 99% of the population recovers from.

Anonymous said...

Actually Pfizer first reported last week that it's vaccine was 90% effective, and then Moderna came out earlier this week and said its was 94.5% effective. Not to be outdone, Pfizer came out yesterday and said its is now actually 95% effective.

(I wonder how Pfizer's rate increased 5% with no more testing done in the last few days. And I supposed Moderna will say tomorrow its is 96%, then Pfizer will say a day later its is 97%, etc...)

Anonymous said...

This is good news. No mention of how long it takes for the vaccine to be effective. For example, the flu vaccine takes 2 weeks to kick in.

Anonymous said...

Admonitions and cautions from anonymous expert @ 2:34. LMAO Get.Over.Yourself.

Anonymous said...

2:59. yes the cold that has killed over 255 thousand in our country, and 1.3 million around the world...

Anonymous said...

We will be in the first public line to get the vaccine. However, if you combine all of the doses of vaccine said to be available (Pfizer and Moderna combined) there is still not sufficient vaccine to vaccinate all health care workers, and IMO, they need to come first, followed by first responders, police, firefighters and perhaps the military. It will likely be sometime in the first quarter before there are any publicly available vaccines for general distribution. IMO, that is the way it should be, and Both the wife and I are in the highest risk groups (Age and heart/respiratory risk).

Regarding Pfizer, their vaccine must be stored at very low temperature and there are very few medical freezing units that will run that low. The company that makes them has 50 employees and says there is no way they can produce the units needed. Moderna has a much more friendly storage temperature requirement and will be more user friendly when shipped and stored. Both vaccines have at least a week long refrigerated storage Lifespan. I can assure you, a vial of vaccine will not last anywhere close to a week, once thawed, since each vial likely will only do less than ten vaccines. I see then thawing them and using the vial in an hour or two. It will eventually get to the point where they tell the public, "We are thawing ten vials tomorrow, so get in line early, or wait until the next day to come get your shot" - or "you must arrange to get vaccinated by appointment only!"

Once they get enough vaccine, they need to vaccinate the way we got vaccinated in the Army. You would line up and march between two guys who had high pressure "guns" that would shoot the vaccine through your skin without a needle. Then they would march you ten miles to work the soreness out of your arms. The only needle shot I can remember ever getting was the plague vaccine.

Anonymous said...

3:04

They had to wait until they got a certain number of cases. One those cases came in, the percentage would either go higher or lower. It went higher.

Anonymous said...

3:04

Obviously Pfizer uses the Dominion software.

Anonymous said...

Now it’s just a game of avoiding the maskless covidiots until the 7.8 billion doses needed to inoculate every human on the planet are widely available. Hopefully the covidiots and anti-vaxxers will pass on it, leaving more the rest of us.

Anonymous said...

"94% effective on a cold over 99% of the population recovers from." Thank you for that post. I agree. Shame they have people so fucking panicked over this. For those salivating at the prospect of this so called we will save the world vaccine, remember the movie "I am Legend" and how that ended.

Anonymous said...

This is great news. Covid is the third leading cause of death in the US for 2020.

Anonymous said...

Once I take one of these vaccines, I am still going to wear a mask. "Don't Thread on Me"

Anonymous said...

Hey anonymous expert @3:14, care to refute anything in the original post at 2:34 or are you just another COVID denier?

Anonymous said...

Vaccines do not work! They kill and maim babies!

My body my choice.

And masks? Bunch of libtards.

Walk it off ya snatches.

Anonymous said...

@3:21, ive got a MUCH better idea about how “we” should get vaccinated. YOU give me a shot if you get past my first “shot”@3:44

Anonymous said...

The troll force is strong today.

Anonymous said...

Here is a great short article about what the military is doing:

https://www.nytimes.com/interactive/2020/11/16/us/virus-military.html?action=click&module=News&pgtype=Homepage

I think the most interesting points: quarantine to weed out unsuitable candidates and the fact that they want to continue many measures even beyond Covid....

Calm Down said...

I don't think the line for the first vaccination will be very crowded.

Jacksun said...

Dead last in priority to receive the vaccine should be 5:21 and the other loud covid deniers. They think C19 is no big deal? Fine, let others receive the vaccine well before they do. And if they get a bad case of C19 in the meantime? Well that's Karma baby!

Anonymous said...

Does the injection contain a microchip or not?

Anonymous said...

Actually 5:21 should be one of the first to receive the vaccine. Such a lack of caring on their part means they are one of the most likely to be spreading the virus. I don't care one bit if they get sick or not, but preventing them from being able to deliberately jeopardizing innocent people is more important.

Anonymous said...

November 18, 2020 at 3:16 PM
One word: Comorbidities

Jacksun said...

1:40pm: There are plenty of young people without comorbidities who have developed long term Covid complications, some become long haulers, some of whom even died. The virus is very unpredictable, and the exceptions prove the rule that this is a dangerous virus. Don't deny the power of nature. It is stronger than you. Respect nature; respect science; respect each other; and quit listening to that quack Scot Atlas or Fox News, OAN, NewsWatch, Donald Trump and other lying propogandists who have politicized a dangerous virus and brainwashed people into thinking the virus is the flu.


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